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KMID : 0352120150300010025
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Journal of Kyung Hee University
2015 Volume.30 No. 1 p.25 ~ p.30
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Effect of Perioperative Intravenous Iron Administration on Transfusion Requirements in Patients Undergoing Unilateral Total Knee Arthroplasty
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Lim Kyung-Jee
Kim Seung-Ju
Lee Sang-Jun
Hwang Woon-Suk
Park Eun-Young
Moon Hyun-Soo
Lee Soo-Kyung
Kim Geon-Sik
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Abstract
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Purpose: Total knee arthroplasty (TKA) is associated with a considerable amount of blood loss and frequently entails allogeneic transfusion. This study was designed to evaluate the effect of perioperative intravenous iron therapy on the transfusion requirements inpatients undergoing unilateral TKA.
Methods: Sixty-four patients classified as ASA physical status 1 or 2 scheduled for elective unilateral TKA were studied. Thirty-two patients scheduled for unilateral TKA were given 300 or 400 mg of intravenous iron sucrose perioperatively (iron group). A previous series of 32 patients who had undergone the same surgery without intravenous iron served as the control group. Allogeneic transfusion was indicated when the hemoglobin (Hb) level fell below 10 g/dL or patients became symptomatic of acute anemia.
Results: Although no statistically meaningful difference in the allogeneic transfusion rate was noticed, the transfusion index in the iron group was lower than in the control group (1.3 vs. 1.8 units/patient, P<0.05). Hb levels measured at discharge were significantly higher in the iron group compared with the control group (11.7 vs. 10.9 g/dL, P<0.001).
Conclusion: Perioperative administration of intravenous iron is a safe and effective method of reducing allogeneic blood transfusion in TKA patients.
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KEYWORD
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Arthroplasty, Blood transfusion, Intravenous, Iron, Knee
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